The region is located in the northwest of the Free State of Saxony.  The region belongs to the area of the regional directorate Leipzig, is located in the district of Leipzig and borders with the municipal area of Borsdorf as well as the urban areas Brandis and Naunhof directly to the urban area of Leipzig. The unifying band of the region is the river Mulde. The LEADER region leipziger Muldenland includes the towns and municipalities of Bad Lausick, Bennewitz, Borsdorf, Brandis, Colditz, Grimma (excluding the districts of Mutzschen, Gastewitz, Göttwitz, Jeesewitz, Köllmichen, Prösitz, Roda, Wagelwitz and Wetteritz), Lossatal, Machern, Naunhof, Otterwisch, Parthenstein, Thallwitz, Trebsen and Wurzen.